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E. vimr phage3/21/2023 For one, scientists were skeptical about how well it worked. However, phage therapy eventually fell out of favor in the West for several reasons. Phage Therapy Falls to the Wayside of Western Medicine pharmaceutical companies produced phage preparations to treat various infections, including those of the upper respiratory tract and abscesses. Nevertheless, phage therapy did have a stint in the U.S. The results were also published in non-English journals, making them largely inaccessible to Western scientists. In any case, d'Herelle's use of phages to combat bacterial infections jumpstarted international efforts-largely centered in the former Soviet Union-to test the efficacy of phage therapy for treating everything from typhoid fever to cholera.Įarly studies were promising, though experiments were often improperly designed by today's standards (i.e., lacked placebos or control groups, among other issues). The French-Canadian microbiologist, Felix d'Herelle, is credited with discovering and naming bacteriophages (though there is debate as to whether d'Herelle or the British microbiologist, Frederick Twort, was the official discoverer of phage). Phage therapy is nothing new-its origins date back over 100 years. The Rise and Fall of Phage Therapy in the West Why? And what needs to happen to make phage therapy mainstream? The answers are entrenched in a tangle of historical skepticism, regulatory and manufacturing hurdles and physiological aspects of phages themselves. Yet, phage therapy has largely existed on the fringes of medicine, particularly in Western countries like the U.S., where it is occasionally approved for compassionate use (i.e., used on an emergency basis when no other approved therapies are available). This specificity makes phage therapy an attractive alternative for managing infections, especially those caused by multi-drug resistant (MDR) bacteria. In contrast to many antibiotics, which obliterate harmful bacteria, while simultaneously decimating the microbiota (thus triggering a new set of problems), each phage has evolved to more narrowly target bacterial strains or species. From the soil to our guts, there are thousands of different types. Phage therapy involves using phages to treat bacterial infections. Bacteriophages, or phages, are viruses that specifically target bacteria.
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